Advantan Cream - a remedy that belongs to the class of topical steroids and is applied topically. The active substance of the cream is methylprednisolone aceponate in a concentration of 0.01%. The cream has an anti-inflammatory, glucocorticoid, anti-allergic effect. It is used to treat the following diseases:
- True eczema;
- Atopic dermatitis;
- Children's eczema;
- Occupational eczema;
- Dyshidrotic eczema;
- Simple and allergic contact dermatitis;
- Microbial eczema.
You should consult a doctor regarding the use of Advantan Cream, as in each case for effective treatment it is necessary to select a certain concentration of the active substance, as well as determine the frequency of use and the duration of the course.
What other factors are needed to determine the dosage and course of treatment:
- The severity of the disease;
- Age of the patient;
- The degree of inflammation;
- Previous treatment and medical history.
Action Advantan Cream
When using Advantan Cream, the following allergic reactions are eliminated: erythema, edema, weeping, itching, pain, irritation. When applied locally, there was no effect on the adrenal glands: the plasma cortisol level remains unchanged.
Advantan Cream underwent clinical trials, during which there were no undesirable side effects with prolonged use (tests were performed for 12 weeks in adults and 4 weeks in children). After use, there were no cases of telangiectasia, striae, acne-like rashes, skin atrophy.
The active substance Advantan Cream binds to glucocorticoid receptors. In turn, the steroid-receptor complex binds to certain sections of the DNA of the cells of the immune response, which causes the production of the substance macrocortin. Macrocortin slows the release of arachidonic acid, slows down the production of prostaglandids and leukotrienes, which lead to inflammation. Since Advantan Cream has a vasoconstrictive effect, you should definitely consult a doctor if you have any chronic diseases.
Absorption through the skin
When using Advantan Cream, the absorption in children and adults was about 2.5%. The indices were the same both with and without occlusive dressing.
Metabolism and excretion
The main metabolite of the active substance (methylprednisolone aceponate) is 6α-methylprednisolone-17-propionate, which is more similar in structure to skin receptors. Contacting glucuronic acid, the metabolite is inactivated and excreted by the kidneys within 16 hours. Neither the active substance nor its metabolites accumulate in the body.
Application and dosage
Advantan Cream is applied a thin layer on the affected skin 1 time per day. Approved for use by children from 4 months and adults. Since clinical trials were conducted for 12 weeks in adults and 4 weeks in children, it is not recommended to use the cream longer than this time on a regular basis. You can apply the cream on the scalp, the composition is well absorbed through the hair.
Advantan Cream practically does not cause side effects. In 0.01% of cases, the following side effects were noted:
- Vesicular rash;
In 0.01-0.1% of cases, the following side effects were reported:
- Periodic dermatitis;
- An allergic reaction to a component of the drug;
- Skin depigmentation.
If Advantan Cream is used systematically for more than 12 weeks for adults and 4 weeks for children, the following may occur:
- Atrophy of the skin;
- Skin changes that can lead to acne.
If side effects occur, stop using the cream.
Contraindications Advantan Cream
Apply Advantan Cream is contraindicated in the following cases:
- Age of the child up to 4 months
- In case of a pronounced reaction to vaccination, the product should not be applied to this area of the skin.
- Tuberculosis process on the skin
- Syphilitic process on the skin
- Chicken pox, shingles, other viral diseases on the skin in the field of application of the cream;
- Rosacea, perioral dermatitis in the field of application of the cream.
The use of cream during pregnancy and lactation
A doctor may prescribe Advantan Cream if the benefit to the mother outweighs the risk to the child. It is not recommended to use the product on large areas of the skin and for a long time. With lactation, you can not apply the cream to the mammary glands.
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