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Viagra sildenafil 100 mg 4 Coated Tablets

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Sildenafil instructions for use 

Sildenafil is a drug for oral use intended to treat erectile dysfunction and pulmonary hypertension. When sexually aroused, the drug restores reduced erectile function by increasing blood flow to the penis. Sildenafil is Generic Viagra, which was the first and primary drug to treat erectile dysfunction and impotence produced by Pfizer.

Medication is classified as a type 5 phosphodiesterase inhibitor. This means that the enzyme is found in the cavernous bodies of the penis and in the small circle of the circulation.

The drug was developed to treat high blood pressure and angina. However, during clinical trials of the drug, the substance was not effective enough. However, researchers have noticed that the drug is effective for sexual dysfunction. 

Sildenafil for pulmonary hypertension

Pulmonary hypertension is a disease of the cardiovascular system characterized by high blood pressure in the pulmonary artery. The pressure rises due to the narrowing of the arteries walls, leading from the heart to the lungs. This forces the heart to work harder to pump blood through the lungs. The extra effort leads to weakening of the heart muscle and the development of serious heart failure.

When taking Sildenafil, the following parameters improved: pulmonary vascular resistance, right atrial pressure, and cardiac output. Patients who received Sildenafil showed a tendency to improve the clinical course of the disease, in particular a decrease in the frequency of hospitalizations for pulmonary hypertension.

Sildenafil vs Tadalafil

Compared to Sildenafil, Tadalafil has a longer half-life (17.5 hours) and its pharmacokinetics are independent of food and alcohol intake.

 

Name

Sildenafil

Tadalafil

Onset of action

30-60 minutes

30-60 minutes

30-60 minutes

6-12 hours

36 hours

Side effects

Nasal congestion, headache, dizziness, visual disturbances, upset stomach.

Stomach upset, headache, discomfort in the back.

 

Contraindications  

Heart disease, liver, and kidney disease.   

Allergies, heart disease. Age under 18 years and over 65 years.

 

 

The duration of action of Tadalafil is 36 hours, which is a great advantage compared to Sildenafil.

Sildenafil for women

In case a woman is asexual, increased blood pressure will not make her feel attracted to her partner. Still, women buy this drug.

Powerful blood flow to the small pelvis, provided by Sildenafil, actively oxygenates the walls of the uterus and fallopian tubes. This has a very positive effect on the maturation and passage of eggs, which is important for conception. The increased pressure of fluids facilitates the work of the excretory system. There is a large amount of lubricant in the vagina – this improves the sensitivity of the female organs and the entire sexual act in general.

Sildenafil and alcohol

Alcoholic beverages reduce the effectiveness of Sildenafil to combat erectile dysfunction by 20-40% (depending on the dosage). Alcohol itself, in addition, negatively affects the urogenital system, makes the heart and liver work harder, and can cause erectile dysfunction. However, it is allowed to combine small portions of alcohol with taking tablets for potency.

Excessive alcohol and Sildenafil can lead to the following effects:

  • tachycardia, a sharp drop in blood pressure, dizziness, confusion;

  • liver failure or even liver failure;

  • additional strain on the kidneys;

  • nervous system dysfunction – headaches, drowsiness, seizures, increased skin sensitivity;

  • muscle pain;

  • prolonged painful erections without ejaculation;

  • respiratory dysfunction. 

Reaction to the joint reception of Sildenafil and alcohol is individual – depends on the dosage, history, age of the patient, and a mass of other factors. In case of severe poisoning with alcohol or Sildenafil: 

  1. Offer a sorbent (activated charcoal, Enterosgel).

  2. Warm the patient with a warm blanket or heating pad with water, and rub the feet and hands.

  3. Offer ascorbic acid (250-500 mg), warm tea with lemon, Rehydron solution, and clean water to restore water-salt balance. 

If your condition worsens, or you lose consciousness, seek medical help immediately.

Sildenafil: headache

Headache is one of the most common side effects of taking Sildenafil. To reduce the side effects of the drug, cancelling Sildenafil, reducing the dose, and using pain medication can help.

Sildenafil: Prescription Online

The drug is dispensed with a doctor's prescription, if you want to buy Sildenafil without a prescription- make an order from our online pharmacy. You will be able to purchase the drug with a prescription from a Mexican doctor on staff at the pharmacy.

Duration of Sildenafil 

Sildenafil 100 mg usually starts working for erectile dysfunction within 30 minutes of taking it. Sildenafil continues to work for up to 4 hours, although its effectiveness decreases after 2 hours.

How long should I take Sildenafil?

Sildenafil 100 mg should not be taken for a long time and exceed the recommended dosage, as the drug has side effects and contraindications. This is a barrier to its use in most men of older age groups. In addition, Sildenafil is not compatible with many of the medications that people over 65 frequently take. In younger men, Sildenafil, when used systematically, is addictive and develops resistance to the effects of the drug. Sildenafil gives a short-term effect, and for the treatment of erectile dysfunction, it is important to eliminate in time the disorders that cause erectile dysfunction.

With prolonged use, there are vegetovascular disorders, such as nausea, vomiting, severe dizziness, and photophobia. Headaches, weakness, ringing in the ears, dryness, and a feeling of sand in the eyes, stool disorders, stuffy nose, palpitations, blurred vision are also possible. 

Sildenafil: Overdose

Taking Sildenafil at a dose of 200 mg or higher did not lead to increased efficacy, but the frequency of adverse reactions (headache, hot flashes, dizziness, dyspepsia, nasal congestion, visual disturbances) becomes more significant.

Treatment: symptomatic. Hemodialysis is ineffective because Sildenafil is firmly bound to blood plasma proteins and is not excreted by the kidneys.

How does Sildenafil affect blood pressure?

Sildenafil can lower blood pressure. The combination with nitrates (drugs that are prescribed for heart pain) is especially dangerous. The combination can cause a dangerous drop in blood pressure.

Dosage of Sildenafil

The initial dose is 50 mg 30 minutes before planned sexual activity. Taking it with food (especially with fatty foods and alcohol) slows down the onset of the effect.

The doctor may adjust the dose depending on its effectiveness. The maximum allowable dose is 100 mg once a day.

Pay attention!

If at the time of sexual intercourse after taking Sildenafil, painful sensations, numbness, or tingling in the chest, arms, neck, or jaw are noted, it is necessary to interrupt the process and immediately consult a doctor.

Sildenafil should not be taken with medications containing Nitroglycerin. At least 6 hours should pass between taking prostate adenoma medications and Sildenafil. 

The mechanism of action of Sildenafil

Under conditions of sexual arousal, nitric oxide is released in the cavernous bodies of the penis. This component activates the enzyme guanylate cyclase, which increases the concentration of cyclic guanosine monophosphate. This process causes the smooth muscles of the cavernous bodies to relax, allowing for improved blood flow in the male penis and the resulting effect of an erection.

Cyclic guanosine monophosphate (cGMP) is broken down in the cavernous bodies by the active ingredient Sildenafil. Suppressing the activity of this substance leads to an increase in the concentration of cGMP, and further to contraction of the smooth muscles of the cavernous bodies, blood flow, and erection. Sildenafil does not increase the production of cGMP, but only inhibits its breakdown. Thus, the drug can cause an erection only with sexual arousal.

In people diagnosed with pulmonary hypertension, Sildenafil increases the concentration of cGMP in the smooth muscle cells of the pulmonary vessels. It causes them to relax, which may lead to their dilatation.

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