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What is Aciphex Pariet rabeprazole 20 mg 28 Tabs


Aciphex Pariet, also known as rabeprazole, belongs to a class of medications called proton pump inhibitors (PPIs). These medications are used to reduce the amount of acid produced in the stomach and are used to treat a variety of conditions associated with excess gastric juice, such as gastroesophageal reflux disease (GERD), stomach and duodenal ulcers, and Zollinger-Ellison syndrome.

Aciphex dosage

The standard dosage of Pariet medication for adults usually starts at 20 mg per day, which is the recommended starting and maintenance dose for most conditions. In some cases, depending on the severity of the condition and the patient's response to treatment, the dose may be adjusted. The maximum dose of Pariet 20 mg per day should not be exceeded without a physician's prescription.

Pariet contraindications

Aciphex Pariet, known medically as the active ingredient rabeprazole, is an important medication in the treatment of diseases associated with excess acid in the stomach. However, like any other medical drug, rabeprazole has a number of contraindications that should be considered before its use to ensure safety and prevent unwanted complications.

Allergies and hypersensitivity

One of the main contraindications to the use of Pariet medication is the presence of allergy or hypersensitivity to rabeprazole or any of the excipients of the drug. Allergic reactions may manifest as rash, urticaria, itching, swelling of the face, lips, tongue or throat, which may result in difficulty breathing and may require immediate medical attention.

Severe hepatic impairment

Patients with severe liver dysfunction should use rabeprazole with caution, as this condition may affect the metabolism of the drug. In some cases, dose adjustment or selection of alternative treatment may be required.

Pregnancy and lactation

The use of Aciphex Pariet during pregnancy and lactation is potentially risky, since there are insufficient data on the safety of the drug for the developing fetus or infant. In these cases, the drug may be administered only if the expected benefit to the mother significantly exceeds the potential risk to the child.

Age restrictions

The use of Pariet in children requires special consideration. Some pediatric patients may require individualized dosing and close medical supervision. It is important to consult a pediatrician before starting rabeprazole treatment in children.

Combination with other medicines

Interaction of Aciphex Pariet with other drugs may enhance or weaken their effect, which requires careful consideration by the attending physician. Particular caution should be exercised in concomitant administration with drugs whose metabolism depends on CYP2C19, such as diazepam, cyclosporine and some anticoagulants.

Prolonged use

Prolonged use of Pariet 20mg may lead to deficiencies of certain vitamins and minerals, particularly vitamin B12, magnesium and calcium, which in turn may affect bone health.


Studies have shown that long-term use of proton pump inhibitors, including rabeprazole, may be associated with an increased risk of bone fractures, especially in elderly patients and those taking the drugs in high doses or for long periods of time.

Atrophic gastritis

There is evidence that long-term PPI use may be associated with an increased risk of atrophic gastritis, especially in patients with Helicobacter pylori infection. Testing for H. pylori and, if necessary, its eradication is recommended before starting treatment with Aciphex Pariet 20 mg.

Zollinger-Ellison syndrome and other hypersecretory conditions

Although rabeprazole is effective in the treatment of Zollinger-Ellison syndrome and other conditions associated with increased gastric acid secretion, it is important to recognize that a higher dose may be required in these patients. This should be monitored by the physician, taking into account the patient's individual response to treatment.

Interaction with food and beverages

Pariet may be less effective when taken concomitantly with certain foods and beverages, especially alcohol, which may increase gastrointestinal irritation. Avoidance of alcohol during treatment with rabeprazole is recommended.

Psychiatric disorders

Cases of psychiatric symptoms, such as depression and hallucinations, have been reported in patients taking PPIs, including rabeprazole. Patients with existing psychiatric disorders should discuss the possible risks with their doctor before starting treatment.

Side effects

It is important to understand possible adverse reactions for correct response and timely referral to a medical professional if they occur.

Gastrointestinal disorders

The most common side effects associated with taking Pariet involve the gastrointestinal tract. These include:

  • Nausea and/or vomiting

  • Diarrhea or constipation

  • Abdominal pain and discomfort

  • Abdominal bloating and gas

  • Dry mouth

Skin reactions

Some patients may experience allergic skin reactions such as:

  • Rash and itching

  • Urticaria

  • Eczema

  • In rare cases, serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrosis

Neurological symptoms

Proton pump inhibitors, including rabeprazole, may cause neurologic side effects:

  • Headache

  • Dizziness

  • Drowsiness or insomnia

  • Paresthesias (feeling of "goosebumps crawling" on the skin)

Psychiatric reactions

On occasion, taking Pariet may be accompanied by psychiatric reactions, including:

  • Anxiety

  • Depression

  • Hallucinations

  • Confusion

These reactions are rare but require immediate professional attention.

Other possible adverse reactions

  • Changes in laboratory values, including increase in liver enzyme levels

  • Muscle weakness, cramps due to low blood magnesium levels

  • There's no reason for the weight to change in one direction or the other

  • Increased fatigue or weakness, which may indicate anemia or other hematopoietic disorders

  •  Kidney problems, manifested by changes in urinary frequency or urine color

  • Rare cases of hypomagnesaemia (low blood magnesium levels), which can lead to further cardiac and muscular abnormalities

  •  Very rare cases of interstitial nephritis, an inflammatory kidney disease that can lead to kidney failure if not treated promptly

Special instructions

Despite the fact that most adverse reactions when using Pariet 20mg are reversible and disappear after discontinuation of the drug, it is important to pay attention to your sensations and reactions of the body during treatment. This is especially true for prolonged use of the drug, which may lead to more serious consequences, such as vitamin and mineral deficiencies affecting overall health.

Mechanism of action of Pariet

Pariet begins to act within one hour of administration, with maximum effect achieved within 2–4 hours. The therapeutic effect usually lasts up to 24 hours after a single dose. The half-life of rabeprazole is approximately 1–2 hours, but its effects last significantly longer due to prolonged proton pump blocking. Rabeprazole is eliminated from the body mainly through the kidneys as metabolites.

Interaction of Aciphex Pariet rabeprazole with other medicines

Aciphex Pariet may interact with a number of other drugs, which may alter their effectiveness or increase the risk of side effects. Particular attention should be paid to concomitant use with drugs whose absorption depends on gastric acidity, such as ketoconazole, itraconazole and other drugs from the azole group, and with some protected antibiotics. You should also avoid combining rabeprazole with atypical antipsychotics and some heart medications without consulting your doctor.

Frequently Asked Questions (FAQ) on the use of Pariet

What is the correct way to take Pariet?

Pariet 20mg should be taken 30 minutes before meals, preferably in the morning. The tablets do not need to be crushed, chewed or sucked, but should be taken whole.

Can Pariet be taken during pregnancy?

The use of Pariet during pregnancy is possible only when prescribed by a doctor, if the expected benefit to the mother exceeds the potential risk to the fetus.

How long can Pariet be taken?

The duration of treatment with Pariet medication depends on the condition for which it is prescribed and is determined by your doctor. Prolonged use may require regular health monitoring.


Aciphex Pariet rabeprazole is an effective treatment for conditions associated with excess stomach acid. It is important to follow the recommended dosage and watch out for possible side effects and interactions with other medications. A medical professional should always be consulted before starting treatment and if there are any questions or doubts, to ensure the maximum safety and effectiveness of therapy.