What is Pentrexyl? Pentrexyl 500 para que sirve

Pentrexyl 500mg Mexico is a drug that contains 500 mg of Ampicillin. 

Ampicillin is a broad-spectrum penicillin indicated for the treatment of a wide range of bacterial infections caused by ampicillin-sensitive microorganisms.

What is Pentrexil 500 used for?

Ampicillin from Mexico, Pentrexil Mexico, is used to treat infections caused by bacteria, viz:

- еar, throat, and nose infections;

- bronchitis and pneumonia;

- infections of the urogenital system;

- gynecological infections; gonorrhea;

- septicemia;

- peritonitis;

- endocarditis;

- meningitis;

- intestinal fevers, gastrointestinal infections.

Parenteral administration is indicated when oral administration is inadvisable.

It is necessary to take antibiotic drugs strictly according to the doctor's indications, the course should not be interrupted prematurely, but you should not take the medicine longer either.

Mechanism of action of Pentrexil tablets

Like other penicillins, ampicillin blocks the formation of the bacterial cell wall.

By having a destructive effect on the cell wall of the bacteria, so that they sink to the bottom. The drug is effective against more different kinds of bacteria than regular penicillin, which characterizes its broader spectrum of action.

How long does Ampicillin 500 mg stay in the system?

After taking Pentrexil Ampicillin 500 mg, only 30 to 60 percent of the active ingredient is absorbed into the blood through the intestinal mucosa. Maximum levels in the blood are reached about two hours after ingestion.

The blood elimination half-life (T½) is approximately 1 hour.

Pentrexyl 500mg: dosage

Pentrexyl Ampicilina 500mg dosage at:

1. Bronchitis: 250 mg 4 times a day.
2. Pneumonia: 500 mg 4 times a day.
3. Infections of the urinary tract: 500 mg 3 times a day.
4. Gonorrhea: 2 g orally. In the treatment of gonorrhea in women, it is suggested that a single dose be repeated.
5. Gastrointestinal tract infections: 500-750 mg 3-4 times daily.

The usual dose for children (under 10 years of age) is half of the usual dose for adults.

Pentrexyl 500mg for throat infection

The usual dose of Pentrexyl for adults (ear, throat, and nose infections) is 250 mg four times per day.

Pentrexyl 500 should be taken orally, half an hour to an hour before meals.

For more severe infections, the recommended dose may be increased, or Ampicillin may be given intravenously or intramuscularly.

Current guidelines for the proper use of antibiotics should be considered. Prescribing should be done according to local or national guidelines for antibiotic use. Whenever possible, the antibiotic should only be used if the microorganisms are confirmed or suspected to be sensitive to the antibiotic.

Pentrexyl: side effects

Pentrexil tablets may cause adverse reactions:

- Hypersensitivity reactions. If these reactions occur, treatment should be stopped. Occasionally, skin rashes, itching, and urticaria may occur. Their frequency is higher in patients suffering from infectious mononucleosis and acute or chronic leukemia of lymphoid genesis.

- Cutaneous reactions such as erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis are rare.

 - As with other antibiotics, anaphylactic reactions may occur in rare cases.

- Rarely, interstitial nephritis may develop.

- Side effects include nausea, vomiting, and frequent liquid stools. Pseudomembranous colitis and hemorrhagic colitis are rare.

- Hepatobiliary disorders.

- As with other beta-lactam antibiotics, hepatitis and cholestatic jaundice are rare. As with most other antibiotics, moderate and temporary increase in transaminases may be observed.

- Blood and lymphatic system disorders.

- As with other beta-lactams, hematologic effects rarely reported include transient leukopenia and thrombocytopenia and hemolytic anemia.

- Lengthening of bleeding time and prothrombin time have also rarely been observed.

Contraindications

Hypersensitivity to beta-lactam antibiotics (e.g., ampicillin, penicillins, cephalosporins) or to any of the excipients.

Interactions

Bacteriostatic antibiotics may interfere with the bactericidal action of Ampicillin.

Like other oral broad-spectrum antibiotics, ampicillin may decrease the effectiveness of oral contraceptives and patients should be warned about this.

Probenecid reduces the renal tubular secretion of Ampicillin. Concomitant administration may lead to increased concentrations of ampicillin in plasma and prolonged excretion of the drug.

Concomitant use of allopurinol and ampicillin may increase the likelihood of allergic skin reactions.

For determination of glucose in urine during ampicillin therapy, it is recommended to use glucose oxidase enzymatic method. Due to the high concentrations of ampicillin in the urine, false-positive results often occur when using chemical methods.