Colchicine is a remedy that affects uric acid metabolism. It is an alkaloid isolated from the corms of the great agave. It has a pronounced analgesic and anti-inflammatory effect in acute attacks of gout.
Colchicine: Mechanism of action
Colchicine is a substance of alkaloid nature, which significantly reduces the movement of leukocytes to the focus of the inflammatory process. This inhibits the uptake by phagocytes of microcrystalline parts of uric acid.
The drug is able to significantly inhibit cell division, stops miosis, stops granulation processes in neutrophils. Colchicine stops the development of amyloidosis, reduces the intensity of formation of amyloid structure fibrils. Colchicine tablets are highly effective in terms of stopping and preventing gout attacks of an acute nature. The therapeutic effect develops during the first day of use (in 75% of patients).
Colchicine: side effects
The use of the generic Colchicine may be accompanied by various side effects:
alopecia of a temporary nature;
If these symptoms or other undesirable effects occur, tell your doctor, who will cancel or reduce the dosage of the drug.
Colchicine for Gout
Colchicine is a podagra drug and is used to prevent and treat gout attacks. Furthermore, Colchicine is used for the prevention and short-term treatment of gout attacks. The drug's action is aimed at reducing the concentration of uric acid in the blood, which is the main cause of the disease. When gout worsens, it is prescribed as an independent drug or in complex therapy.
It is necessary to protect the patient from taking a larger dose of Colchicine tablets than prescribed by the doctor. If more pills than necessary are taken, it is important to contact a doctor or the nearest emergency room immediately, and you should have the instructions for the drug with you.
If the patient forgot to take the next dose of Colchicine at the specified time and missed taking the drug, the treatment regimen is not changed. The next time you take the medicine, the dose should not be doubled.
The drug is taken orally with some water. In acute attacks of gout and inflammatory processes: on the 1st day – 1 mg 3 times a day (1 tablet in the morning, afternoon, and evening), on the 2nd and 3rd days – 1 mg 2 times a day (1 tablet in the morning and evening), on the 4th and subsequent days – 1 mg per day (1 tablet in the evening).
For the 2nd regimen: the initial dose is 1 mg, then 0.5-1.5 mg at intervals of 1-2 hours until the pain disappears. The maximum daily dose is 6 mg. For the prevention of gout attacks, the patient has to take 1 mg in the evening; the course is 3 months.
For recurrent disease complicated by amyloidosis, 1-1.5 mg daily for a long time (up to 5 years or more). For elderly patients or patients with impaired renal function, it may be necessary to reduce the dose or frequency of administration of the drug.
What is Colchicine used for?
The drug is effective for the following conditions:
Acute attacks of arthritis resulting from an exacerbation of gout;
Prevention of gout attacks;
For the treatment of acute and recurrent pericarditis;
Phlebitis (some forms);
Pathologies of inflammatory nature in ENT practice;
Pathologies of inflammatory nature in dentistry;
Familial Mediterranean fever.
Read the information for the drug before using it, as Generic Colchicine has various contraindications.
Do not take Colchicine tabs if you have:
- Hypersensitivity to the active ingredient or any of the excipients;
- Severe heart or kidney failure;
- Diseases of the gastrointestinal tract;
- Period of pregnancy and lactation;
- Contraindicated in patients receiving hemodialysis treatment;
- Blood dyscrasia.
Treatment with Colchicine generic is carried out with careful clinical and hematological monitoring, periodically monitoring fecal occult blood content.
Interaction with other medicinal products and other types of interactions
- Thiazide diuretics may increase serum uric acid levels and may inhibit the effects of Colchicine.
- Colchicine may decrease the absorption of vitamin B12 and in combination with Cyclosporine may provoke muscle damage.
- Concomitant use of Clarithromycin, Erythromycin, or Tolbutamide may enhance the effect of Colchicine and intoxication with the latter.
- Concomitant use of Colchicine with non-steroidal anti-inflammatory drugs and other drugs causing myelosuppression increases the risk of leukopenia and thrombocytopenia.
- Simultaneous intake of alcohol may increase intoxication with Colchicine.
- Colchicine generic may be used in combination therapy with Allopurinol and uricosuric drugs.
Symptoms of overdose:
Generic Colchicine may appear several hours after taking the drug. The first signs are a burning sensation in the throat, in the mouth, nausea, vomiting, thirst and diarrhea (diarrhea may be severe, with blood), urges to urination and defecation, tenesmus, colic, usually with a fallen stomach.
There is a burning sensation on the skin. Metabolic acidosis, dehydration, tachycardia, sensation of pain and compression in the heart area, decreased body temperature, pale skin, cyanosis and dyspnea, visual disturbances, arterial hypotension and shock are possible. Cases of disseminated vascular damage and acute nephrotoxicity with oliguria and hematuria have been reported.
Patients may experience seizures, delirium, muscle weakness, neuropathy and ascending central nervous system paralysis. Respiratory and cardiovascular failure may develop, or bone marrow function may be inhibited, with fatal outcomes.
The fatal (lethal) dose varies. A fatal case was recorded after receiving Colchicine at a dose of 7 mg or higher.
Treatment: hospitalization of the patient is necessary. There is no specific antidote. Hemodialysis is ineffective. Gastric lavage should be performed.
Symptomatic and supportive therapy with mandatory monitoring of respiratory function (if necessary, artificial ventilation is established), cardiovascular system (ECG control), maintenance of blood pressure and circulation and correction of fluid and electrolyte balance.read more