Supradol Ketorolaco 30 mg is a non-steroidal anti-inflammatory medication (NSAID) that is used to reduce the pain from mild and moderate to severe, and to treat inflammation and fever.
The mechanism aims to inhibit the activity of COX1 and COX2, which play a significant role in the pathogenesis of pain, inflammation, and fever.
What is Supradol used for?
Supradol (Ketorolac) is indicated for the treatment of:
- Acute postoperative pain
- Soft tissue and spine pain
- Rheumatoid arthritis
- Menstrual pain (Dysmenorrhea)
- Renal colic
Ketorolac is comparable to Morphine in its analgesic effect and is significantly superior to other NSAIDs. Supradol does not affect opioid receptors, does not depress respiration, is not addictive, and has no sedative and anxiolytic effects.
After oral administration, the onset of analgesic effect is noted after 1 hour, the maximum effect is achieved after 1-2 hours.
Hold the tablet Supradol 30 mg under the tongue for a few seconds until complete dissolution. If desired, you can drink the liquid.
The tablet dissolves in the oral cavity, does not require compulsory drinking water, does not impact the production of saliva, and allows the drug to be taken by patients with dysphagia, as well as behavioral and neurological disorders.
Supradol (sublingual) is administered orally once or a few times, depending on the severity of the pain syndrome.
Supradol Ketorolaco 30 mg sublingual are supplied in boxes of 2, 4, or 6 tablets. Recommended dosage: For adults, the dosage is 30 mg 1-2 times per day. Not suitable for children under 12 years of age. When taken orally, the duration of the course should not exceed 5 days.
Often, a parenteral method of administration is prescribed in hospital conditions. When switching to the tablet form, the doctor prescribes a dose not exceeding 90 mg daily for patients aged 12 to 65. If the patient is over 65 or has a history of serious renal dysfunction, the daily dose may be reduced to 60 mg.
When is Supradol contraindicated?
Despite the effectiveness of the drug, you should consult your doctor before using it, since Supradol Ketorolac has a number of contraindications, the main ones being
- Hypersensitivity to this drug or an allergic reaction to other NSAIDs
- A peptic ulcer in the active phase
- Patients with severe heart failure
- Moderate to severe renal insufficiency
- Bleeding and other blood clotting disorders
Important contraindications are also pregnancy, lactation period, and children under 12 years of age. Supradol (Ketorolac) should not be used in combination with other NSAIDs, ASA, or anticoagulants.
Possible side effects
Supradol 30 mg tablets may cause gastrointestinal side effects such as peptic ulcer, gastrointestinal perforation, and bleeding.
Other conditions that may occur after taking Supradol:
- Impaired metabolism and digestion of food. Anorexia and high levels of potassium and sodium in the blood are observed
- Damage to the central nervous system in the form of seizures, drowsiness, dizziness, and headaches. Often there is a decrease in concentration, anxiety, and insomnia
- Sometimes there is mental disturbance like anxiety, abnormal thinking and clairvoyance, hallucinations and nervousness
- From kidneys and urinary tract: frequent urination or retention of urine. Renal pain, rarely a renal failure
- Cardiovascular system: swelling, high blood pressure, arrhythmia, chest pain, pale skin
- Women have disorders of the reproductive system and mammary glands
- Liver and biliary tract: liver dysfunction, jaundice, sometimes liver failure
- Musculoskeletal system and connective tissue: pain in muscles and joints
- Some patients noticed visual impairment and tinnitus
Side effects occur less frequently if the patient strictly observes the conditions of use. This means that the indications, dosages, and duration of treatment indicated by the doctor must be strictly followed.
Interaction with other drugs
Due to the possibility of side effects, the drug should not be prescribed with other NSAIDs, including selective cyclooxygenase-2 inhibitors, or patients receiving Acetylsalicylic acid, Warfarin, Lithium, Probenecid, or Cyclosporine.
Supradol attenuates the effect of antihypertensive drugs. Concomitant use of Ketorolac with angiotensin–converting enzyme (ACE) inhibitors increases the risk of renal failure, especially in patients with reduced blood volume in the body.
There is a risk of nephrotoxicity when concomitant use of NSAIDs with Tacrolimus. Concomitant use with diuretics may lead to weakening of the diuretic effect and an increased risk of nephrotoxicity of NSAIDs.
Increased risk of gastrointestinal bleeding when NSAIDs are prescribed in combination with antiaggregants and selective serotonin reuptake inhibitors. Do not drink alcohol during treatment, as it may cause a risk of gastric bleeding.read more