Indomethacin suppository is a non-steroidal anti-rheumatic and anti-inflammatory drug. The active ingredient is Indomethacin. The regulatory ingredients are solid fats. Indomethacin suppository comes in the form of a cylindro conical shape, has a smooth surface of white or yellowish color, odorless. When cut, funnel-shaped depressions can be seen, and there may be a porous or airy rod.
Indomethacin has a high anti-inflammatory property, which has inhibitory effects on the enzyme cyclooxygenase, reduces the production of prostaglandins, prevents the onset of inflammation, and reduces pain syndromes. It is characterized by an antipyretic effect.
Indomethacin suppository is administered rectally, being rapidly resorbed up to 80-90%. Within 1-2 hours, it reaches maximum accumulation in the liquid part of the blood. It is distributed throughout all tissues and organs. Penetration occurs through the blood-brain and placental barrier. Indomethacin, when taken simultaneously with other drugs, has the ability to increase its effectiveness. It is completely metabolized in the liver by conjugation and oxidation. It is eliminated from the body in a little over 11 hours. About 75% is excreted by the kidneys, the rest is excreted with the bile and feces, and up to 20% is excreted unchanged. It penetrates into the breast milk.
During short-term symptomatic treatment with the drug, the efficacy of Indomethacin is established in acute and frequently recurrent pain, in inflammatory diseases of the musculoskeletal system and periarticular tissues, arising from inflammatory processes.
- Hypersensitivity to Indomethacin, manifested by allergic attacks
- Severe renal or hepatic impairment
- Complicated heart failure
- Ongoing gastric and duodenal ulcer or if recurrent
- Various colitis
- Internal bleeding associated with concomitant administration of similar agents
- Increased levels of urea
- Weight gain
- Altered liver enzymes
- Increased sweating
- Increased blood sugar
- Seizures, agitation, muscle hypotonicity, or uncontrolled muscle twitching
- Mental disorders, impaired consciousness, coma
- Disorientation, hallucinations, insomnia, drowsiness, depression, fatigue
- Pain near the eye area, decreased vision, conjunctivitis
- Deterioration of hearing
- Change in heart rhythms
- Taste disorders, gastroenteritis, gastric erosion and ulcers, stomach bleeding
- Hair loss, eczema, various skin rashes
When taking Indomethacin simultaneously with other drugs, the risk of the following adverse reactions increases:
Salcitabine - there is a decrease in its effectiveness and action
Zidovudine – increases the myelotoxicity of Indomethacin and the risk of hematologic toxicity
Ritonavir – manifests itself in the toxicity of Indomethacin
Antiepileptic drugs – increases the effects of phenytoin
Haloperidol – increases drowsiness
Benzodiazepines – increases the risk of grogginess
Desmopressin – increases the effect of the substance
The drug increase the risk of analgesic nephropathy and renal papillary necrosis with substances that inhibit enzymatic processes.
Digoxin – increases blood fluid concentrations of this drug
Lithium salts, immunosuppressants – increased toxicity of these substances may occur
Muromonabam-CD3 – raises the risk of psychiatric disorders and poor blood circulation in the brain
Tacrolimus, diuretics, and Probenecid – increases the toxicity of Indomethacin while reducing the effectiveness of these agents
Cyclophosphamide – the risk of poisoning
Antihypertensive medications – Indomethacin reduces their effectiveness
Corticosteroids – may cause gastrointestinal bleeding
Antibacterials – may cause seizures
Ciprofloxacin – the risk of skin reactions
Antidiabetic drugs – Indomethacin does not cause adverse reactions
The recommended dosage of Indomethacin suppository is 1 suppository of 50 mg 1-3 times a day or 1 suppository of 100 mg at a time. If there is systematic pain at night or morning stiffness, it is recommended that the suppository be used before bedtime in a dose of 100 mg. It is not safe to exceed a dose of over 200 mg. Indomethacin is prescribed at an initial dose of 50 mg 2-3 times a day. Increasing the dose should be coordinated with the attending physician. It is not recommended for children under 14 years of age.
How long does Indomethacin stay in your system?
The drug is excreted from the body for about 12 hours. About 75% is excreted by the kidneys, the rest is taken out with the bile and the feces, and up to 20% is excreted unchanged.
Indomethacin is contraindicated during pregnancy and lactation because it tends to cross the placental barrier and penetrate into breast milk.
Indomethacin for headache, and migraine
This medicine has a strong anti-inflammatory effect, which is more effective than acetylsalicylic acid and Phenylbutazone. In this regard, Indomethacin is considered the right choice in the treatment of chronic paroxysmal and prolonged hemicrania, as well as in the emergency therapy of migraine and various types of primary headache.
Indomethacin: Dosage for gout
Gout medication Indomethacin helps relieve an acute attack of gout. It is also used for gouty arthritis and other joint conditions. To relieve a sudden attack of gout, initially take 200 mg, subsequently, take 50 mg three times a day until the pain stops.
Indomethacin and alcohol
The drug is not compatible with alcohol, in any form, be it tablets, ointment, or suppositories. The effects of alcohol on taking this medication may not only have unpleasant consequences, but may also be life and health-threatening.
Despite the high effectiveness of the drug, it has a fairly low cost. If you want to get effective results at a low cost, then ask and order Indomethacin in our online pharmacy.
Where can you buy Indomethacin?
You can buy Indomethacin in our online pharmacy. Send the product to the cart and fill out the application form, provide your name and home address. We deliver Indomethacin to all cities in Mexico and the United States, at affordable prices.read more