Lisinopril Prinivil Zestril Generic 10 mg 28 tabs

If its all the same to you guide your specialist before taking any remedy. Non particular Name: lisinopril (lyse IN goodness pril) Brand Names: Prinivil, Zestril What is lisinopril? Lisinopril is in a get-together of meds called ACE inhibitors. Professional stands for angiotensin changing over compound. Lisinopril is used to treat (hypertension), congestive heart frustration, and to improve survival after a heart ambush. Lisinopril Prinivil Zestril online may similarly be used for purposes other than those recorded in this remedy helper.

Pharmachologic effect

Inhibits ACE, prevents the transition of angiotensin I to angiotensin II, increases the concentration of endogenous vasodilating PG. Reduces the formation of arginine-vasopressin and endothelin-1, which have vasoconstrictor properties. Lowers OPSS, systemic blood pressure, afterload on the myocardium, pressure in the pulmonary capillaries. Increases cardiac output and myocardial tolerance to stress in patients with heart failure. Increases (secondarily) plasma renin activity. The effect manifests itself after 1 h, increases within 6–7 h, lasts up to 24 h. The antihypertensive effect reaches optimal values ​​with repeated administration over several weeks. Inhibits the tissue renin-angiotensin system of the heart, prevents the development of myocardial hypertrophy and dilatation of the left ventricle, or contributes to their reverse development (cardioprotective effect). Reduces the number of sudden deaths, reduces the likelihood of recurrent myocardial infarction, impaired coronary blood flow and the occurrence of myocardial ischemia. According to the ATLAS study in patients with chronic heart failure, the use of lisinopril in high doses (35 mg), compared with its use in low doses (5 mg), reduced the combined indicator: total mortality + all causes of hospitalizations by 12%, the number of hospitalizations - by 13%, the number of hospitalizations for decompensated heart failure - by 24%. The results of the CALM study (combination therapy with candesartan and lisinopril) showed greater severity of nephroprotective and hypotensive effects in the group of patients who received the combined treatment after 24 weeks.

When lisinopril was administered to rats for 105 weeks at doses up to 90 mg / kg / day (56 times more than MRDC) and mice for 92 weeks at doses up to 135 mg / kg / day (84 times higher than MRDC), no signs of carcinogenicity were found . Mutagenic and genotoxic properties does not possess. At doses up to 300 mg / kg / day, it does not adversely affect reproductive function in male and female rats. The administration to mice on the 6–15th day of gestation in doses up to 625 times higher than MRDR was not accompanied by manifestations of teratogenic action. In rats treated on the 6–17th day of pregnancy, doses 188 times higher than mRDC did not show a teratogenic and fetotoxic effect, although there was a decrease in the average body weight of newborn rats.

However, it should be borne in mind that in humans, the use of other ACE inhibitors during pregnancy may cause an increase in fetal and neonatal mortality, and the administration in trimesters II and III is accompanied by a decrease in the mass of the placenta, delayed skeletal ossification, the development of low water (due to a decrease in kidney function), anuria , renal failure in the fetus, including death, pulmonary tissue hypoplasia, limb contractures and craniofascial deformities, non-opening of the Botallov duct and more toxic influence on the mother’s body.

After ingestion, about 25% is absorbed (6–60%). Food intake does not affect absorption. It binds poorly to plasma proteins (6–10%). Not biotransformed and excreted by the kidneys unchanged, T1 / 2 is 12 hours. Clinically significant changes in pharmacokinetic parameters requiring correction of the dosing regimen are observed when the glomerular filtration decreases less than 30 ml / min (plasma Cmax increases, T1 / 2 lengthens and the duration .) In elderly patients, plasma concentration and AUC increase by 2 times. Removed by hemodialysis. With the introduction of rats slightly passes through the BBB, does not accumulate in the tissues with repeated use, is found in breast milk and placenta (but not in the tissues of the fetus).

Indications

Arterial hypertension (mono- and combination therapy), incl. renovascular; chronic heart failure (as part of combination therapy for the treatment of patients taking digitalis and / or diuretics); acute myocardial infarction (in the first 24 hours with stable hemodynamic parameters to maintain these indicators, as well as to prevent dysfunction of the left heart chamber and heart failure); diabetic nephropathy (to reduce albuminuria in insulin-dependent patients with normal blood pressure and insulin-independent patients with arterial hypertension).

Contraindications

Hypersensitivity to lisinopril or other ACE inhibitors; angioedema in history, including and from the use of ACE inhibitors, hereditary angioedema, or idiopathic edema; pregnancy, breastfeeding, age up to 18 years (safety and efficacy have not been determined).

Carefully

An assessment of the risk-benefit ratio is necessary in the following cases: cerebrovascular diseases (including cerebrovascular insufficiency), coronary artery disease, coronary insufficiency, collagenoses (including systemic lupus erythematosus, scleroderma), bone marrow hematopoiesis suppression, arterial hypotension, aortic mitral stenosis or others about

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